Endocrine Abstracts

Introduction: Denosumab is a new pharmacotherapy option for postmenopausal osteoporosis. It is a human monoclonal antibody against RANKL, acting as an osteoprotegerin (OPG) analog. Recently, osteoprotegerin levels were found to be elevated in type two diabetes while insulin resistance was shown to be positively associated with decreased serum OPG levels, in healthy obese subjects. However, no study has been conducted in order to clarify the effect of anti-RANKL factors adminis...

Background: Recent studies have suggested an important role of advanced glycosylation end products receptor (RAGE) in the development of atherosclerosis. However, investigation of the relationship between RAGE polymorphisms (−429T/C, −374T/A) and coronary heart disease (CHD) has shown contradictory results. Furthermore, hyperandrogenemia in women postmenopause has been associated with an adverse CHD risk profile.Aim of the study: To investiga...

Introduction: Tyrosine kinase inhibitors (sorafenib and sunitinib) have been used in treating refractory cases of thyroid cancer. The aim of our present study was to assess the efficacy of these agents in patients with refractory and progressive thyroid cancer, regarding patients’ quality of life, adverse events and response ratesPatients and methods: We retrospectively analyzed data of adult patients with differentiated and medullary thyroid cancer...

Context: Evidence suggests that gabapentin, a γ-aminobutyric acid analogue, is effective in the treatment of hot flushes in women with natural or tamoxifen-induced menopause.Objective and design: To investigate the efficacy and tolerability of gabapentin for the treatment of menopausal hot flushes, a systematic review of all pertinent trials and a meta-analysis of those that were randomized placebo-controlled (RCT) were performed.<p class="abste...

Background: Swyer syndrome is a type of pure gonadal dysgenesis 46 XY caryotype in phenotypically female patients. A rare case of Swyer syndrome complicated by dysgerminoma and Retiform Sertoli-Leydig cell’s tumor is reported.Case presentation: A 20-year-old phenotypically female patient presented to our department with primary amenorrhea. She was 1.68 m and weighed 82 kg (BMI 28). She presented with minimal breast development, sparse axillary and p...

Background: Conflicting results regarding adiponectin levels in women with polycystic ovary syndrome (PCOS) have been reported. To evaluate adiponectin levels in PCOS, a systematic review of all studies comparing adiponectin levels in women with PCOS to healthy controls and a meta-analysis of those involving women with similar Body Mass Index (BMI) were performed. Influence of possible effect modifiers, such as insulin resistance (IR) and testosterone, was investigated. Influe...

Introduction: Bisphosponates have long been used with success in the treatment of Paget’s disease of bone (PDB). The aim of this study was to evaluate the early (up to three months) and late (at twelve months) scintigraphic, biochemical and clinical response to a single intravenous infusion of zoledronic acid (ZOL) in patients with PDB serially assessed for one year.Materials and methods: Nine patients with 30 bone lesions due to PDB were prospectiv...

IntroductionThe routine assessment of postmenopausal women involves screening for cardiometabolic risk factors and bone health. Evaluation of the liver function is not commonly performed, even though this could be easily performed with the use of indirect markers, such as the Fibrosis 4 score. Recent evidence supports an association between liver cirrhosis and bone turnover, affecting both the trabecular and the cortical bone. Therefore, we aimed to expl...

IntroductionThe aim of the present feasibility study was to examine the impact of an Internet of Things (IoT) telemonitoring program, for elderly patients with type 2 diabetes mellitus (DMT2) on glycemic control.MethodsIn this feasibility, prospective, randomized, single-blinded, multicenter study elderly patients with DMT2 capable to use the IoT telemonitoring device, with an HbA1c > 7.5 were followed-up...

Hypokalemia has been observed in cases of the new SARS-CoV-2 infection. It has been suggested that hypokalemia may be a sensitive biomarker of disease severity and the requirement for invasive mechanical ventilation requirement in COVID-19 pneumonia. The aim was to describe the case of a patient with severe SARS-CoV-2 pneumonia who developed severe hypokalemia. A patient, male, aged 52, presented with fever and dry cough. He was found to be positive for the SARS-CoV-2 infectio...